Acute and Critical Care

Case Reports

Toxicology
Unexpected Multiple Organ Infarctions in a Poisoned Patient: Sung-Wook Park, Sang-Kyoon Han, Seok-Ran Yeom, Soon-Chang Park, Sung-Hwa Lee; Korean J Crit Care Med. 2015;30(3):227-230. Published online August 31, 2015; DOI: https://doi.org/10.4266/kjccm.2015.30.3.227

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Abstract PDF: Predisposing factors for venous thrombosis can be identified in the majority of patients with established venous thromboembolism (VTE). However, an obvious precipitant may not be identified during the initial evaluation of such patients. In the present case, a 47-year-old female presented to the emergency department of our hospital after ingesting multiple drugs. She had no VTE-related risk factors or previous episodes, nor any family history of VTE. After admission to the intensive care unit sudden hypoxemia developed, and during the evaluation cerebral, renal, and splenic infarctions with pulmonary embolisms were diagnosed. However, the sources of the emboli could not be identified by transthoracic echocardiography or computed tomography angiography. Protein C deficiency was identified several days later. We recommend that hypercoagulable states be taken into consideration, especially when unexplained thromboembolic events develop in multiple or unusual venous sites.

Toxicology
Acute Colchicine Poisoning Treated with Granulocyte Colony Stimulating Factor and Transfusion: Sung-Hwa Lee, Sung-Wook Park, Sang-Kyoon Han, Soon-Chang Park; Korean J Crit Care Med. 2015;30(3):207-211. Published online August 31, 2015; DOI: https://doi.org/10.4266/kjccm.2015.30.3.207

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Colchicine poisoning is rare but can cause potentially life-threatening toxic complications such as hypovolemic shock, cardiovascular collapse and multiple organ failure. In this case report, we describe a case of a 20-year-old female who presented to the emergency department after suicidal ingestion of a toxic dose of colchicine. She developed thrombocytopenia, neutropenia and acute respiratory distress syndrome that required blood transfusion and administration of granulocyte colony stimulating factor for the prevention of infectious complications. With regard to the clinical manifestations of colchicine toxicity, we discussed suggested mechanisms.

Citations

Citations to this article as recorded by

Severe colchicine poisoning treated successfully with kidney replacement therapy and plasmapheresis: a case report
D. H. Schaffer, D. L. Overbeek, T. B. Erickson, E. W. Boyer, C. Goldfine, S. A. Muhsin, P. R. Chai
Toxicology Communications.2022; 6(1): 46. CrossRef

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